Whether mild or severe, data from the U.S. Centers for Disease Control and Prevention (CDC), has shown that women are bearing the brunt of vaccine reactions, and experts believe it may be due to . There have been multiple studies on blood types and COVID-19 risk. The Public Health Agency of Canada, Health Canada, and provincial and territorial health authorities continue to: Nat Commun (2020) 11:5761. doi:10.1038/s41467-020-19623-x, 20. Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. In the case of the two mRNA COVID-19 vaccines, well over 90% of . 38 Articles, This article is part of the Research Topic, https://doi.org/10.3389/fimmu.2023.1107866, https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, Creative Commons Attribution License (CC BY). April 5, 2021. Environ Res (2022) 215:114131. doi:10.1016/j.envres.2022.114131, 3. (EG) Kinetics of interferon (IL)-6 levels according to (E) age, (F) vaccine manufacturer, (G) occupation and (H) interval between doses of vaccination. From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. government site. After adjusting for age, sex, occupation, blood type, interval between doses of vaccination, vaccination duration, and BMI, the highest geometric mean concentration (GMC) of neutralizing antibodies was 53.1 IU/mL in the same-manufacturer vaccination group at 1530 days, which was slightly but significantly higher than the 44.6 IU/mL found in the mixed-manufacturer vaccination group (p < 0.001) (Table2; Figure2B). There were no differences in the positive rate of neutralizing antibodies between the groups throughout the observation period (p = 0.891; Figure2A). Interested candidates contacted one of the study institutions directly; at this point, a personal interview was scheduled to explain the study and verify the selection criteria. A review of neurological side effects of COVID-19 vaccination. Blood type, the researchers found, stood out as a potential key difference between the two groups. Progress and challenge of COVID-19 vaccine development. if( navigator.sendBeacon ) { Individuals vaccinated with different vaccines, those with blood type A, and workers had weaker humoral and cellular immune responses to vaccines than those vaccinated with the same vaccine, those with blood type B, and medical staff. The blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (57% vs. 38%, P < 0.001; OR: 2.1). A previous study in the journal Blood Advances from 2020 also affirmed this research, adding that people with Type O blood seem to be more protected from Covid. Most participants rapidly developed neutralizing antibodies after two doses of the Chinese COVID-19 inactivated vaccine administered 3 weeks apart. The studies involving human participants were reviewed and approved by the ethics committee of Henan Provincial Peoples Hospital. Except for blood type, all demographic and baseline characteristics were balanced between the intervention and control groups (Table1). In this study, a higher frequency of adverse events reported by participants in the mixed-manufacturer vaccination group. Associations were observed between blood type and production of neutralizing antibodies and IFN-. Anderson disclosed no relevant relationships with industry. 8 A total of 3 643 918 persons were enrolled in v-safe and completed at least 1 health survey within 7 days following their first vaccine dose; 1 920 872 v-safe participants reported receiving a second vaccine dose and completed at . The log-transformed level of interferon-gamma, CD4+ T-cell count, B-lymphocyte count, and IL-6 level were used as independent variables. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. Neutralizing antibody levels usually increase after the second administration of mixed vaccines (22, 23). Research in other countries has shown that the antibody titer of individuals vaccinated with a different type of vaccine 28 days after the first vaccination was higher than that of individuals vaccinated with a vaccine from the same manufacturer for both doses, without an increase in adverse reactions (14). Blood type is actually a pretty weak player, Dr. Udden says. To date, most of the Chinese population has been vaccinated with the inactivated vaccine. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). Case Rep Infect Dis. Comment on "SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fiber neuropathy by J. Finsterer. Opens in a new tab or window. PMC The difference may be the type of antibodies we produce depending on blood type. Table4 Factors associated with CD4+ T-lymphocyte count after the administration of the Chinese inactivated COVID-19 vaccine. COVID19 vaccination acceptance among healthcare workers and nonhealthcare workers in China: a survey. doi:10.1002/jmv.27825, 10. sharing sensitive information, make sure youre on a federal Before The first hint of a possible relationship came in March, from researchers in China, who compared nearly 2,200 hospitalized COVID-19 patients to a control group of approximately 27,000 healthy individuals. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. That year, research in the journal .css-16acfp5{-webkit-text-decoration:underline;text-decoration:underline;text-decoration-thickness:0.125rem;text-decoration-color:#d2232e;text-underline-offset:0.25rem;color:inherit;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}.css-16acfp5:hover{color:#000;text-decoration-color:border-link-body-hover;background-color:yellow;-webkit-transition:all 0.3s ease-in-out;transition:all 0.3s ease-in-out;}PLOS Genetics revealed that people with Type A blood are more likely to have a severe case of Covid-19. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. Serious side effects. IntroductionIn China, the long-term immunogenicity and adverse effects of inactivated vaccines produced by different or the same manufacturer remain unclear. In both groups, most of the adverse events were mild (n = 25, 81.1%) or moderate (n = 6, 18.9%) and self-limited. Kaulen LD, Doubrovinskaia S, Mooshage C, Jordan B, Purrucker J, Haubner C, Seliger C, Lorenz HM, Nagel S, Wildemann B, Bendszus M, Wick W, Schnenberger S. Eur J Neurol. Epub 2022 Jun 1. In November 2021 in The New England Journal of Medicine, he proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects, and he called for more basic research to probe possible connections. A total of 1,350 serum samples were collected from 595 participants (Figure1), of whom 457 (76.8%) were medical staff and 138 (23.2%) were workers of the Henan Electric Power Exploration Company in central China. Type B Negative. For a March study out of the Southern University of Science and Technology in Shenzhen, China, scientists tracked the blood types of nearly 2,200 COVID-19 patients in Chinese hospitals, along with those of about 27,000 individuals who didn't have COVID-19 in the same areas. At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. HHS Vulnerability Disclosure, Help Julita Mir, M.D., Infectious Disease Physician and . J Clin Epidemiol (2022) 144:16372. FOIA document.addEventListener( 'DOMContentLoaded', function() { Ai J, Zhang H, Zhang Q, Zhang Y, Lin K, Fu Z, et al. According to a CDC study which analyzed the first month of vaccinations, more than 79% of side effects were reported by women, even though women only accounted for 60% of vaccinations given.. The levels of IFN- and CD4+ T-lymphocytes were not altered in the participants for 240 days after vaccination, whereas the levels of neutralizing antibodies, B-lymphocytes, and IL-6 decreased with increasing time after vaccination. YY and JX designed the study, analyzed the data, and wrote the manuscript. All studies so far have only looked at blood type in connection to symptomatic cases of coronavirus, Dr. Aronoff points out. In addition, other variables, including sex, occupation, vaccination type, and blood type, based on their natural classification, were divided into different categories. J Med Virol (2022) 94:411524. Among 11,000 patients, blood type A was not associated with increased viral positivity (OR 0.97, 95% CI 0.93-1.01, P=0.11), hospitalization (OR 0.89, 95% CI 0.80-0.99, P=0.03) or ICU admission (OR 0.84, 95% CI 0.69-1.02, P=0.08) compared to type O, and neither were there associations with worse outcomes among patients type B or AB, reported Jeffrey Anderson, MD, of the University of Utah School of Medicine in Salt Lake City, and colleagues. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 2022 Aug 15;369:577901. doi: 10.1016/j.jneuroim.2022.577901. The most common side effect of the vaccine is temporary soreness and swelling at the injection site. doi:10.3760/cma.j.cn112147-20200928-01013, 5. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. as it pertains to all aspects of your daily life. In the future, we will include more participants after administering booster vaccines and conduct pseudo-virus neutralization tests to address these limitations. And guess what: People with Type A blood have higher levels of VWF naturally than people with type O blood, Dr. Udden points out. You'll always want to stay at your vaccination site for at least 15 minutes after you get the shot (30 minutes if you've had a severe allergic reaction before). COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. JAMA (2021) 326:204354. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. Vous pouvez modifier vos choix tout moment en cliquant sur le lien Tableau de bord sur la vie prive prsent sur nos sites et dans nos applications. Common side effects included: tenderness at the injection site for 73% of participants pain upon and after vaccination for 60% of participants fatigue for 50% of the participants muscle pain. Med Sci Monit (2022) 28:e938532. If You Have One of These Blood Types, You May Be Safe From COVID, It Only Takes This Long to Get COVID in a Room With Someone Who Has It, These 2 Places Could Be Closing Soon, White House Official Warns, How Likely You Are to Catch COVID in the Next Month, Expert Says, If You Have This Symptom, There's an 80 Percent Chance You Have COVID, tracked the blood types of nearly 2,200 COVID-19 patients, A blood types were significantly more likely.